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Therapeutic History

Medical gases trigger naturally occurring physiological responses, enhancing the human body’s preventive and self-healing capabilities. Until the invention of the AirJector®, medical gases were only available for highly invasive applications and inhalation therapies and in wellness facilities and thermal springs where carbonated and oxygenated water is naturally available. Now, these highly effective medical solutions are made broadly available by the AirJector® system. Treatment providers and self-care users can take advantage of the benefits of medical gases as part of their overall treatment regimen.


Practiced for centuries using carbonated waters, systematic and skilled medical gas therapy is fast becoming better understood within the context of the natural sciences, especially in treating cardiac and peripheral vascular disorders. No natural remedies can make use of such a broad and diverse base of knowledge as medical gas treatments.


Before AirJector’s unique H2O/CO2 vapor mixture-based therapy existed, only naturally occurring carbon dioxide (natural carbonated springs) had been applied for CO2 balneotherapy treatments noninvasively. Since natural springs are restricted to specific geographic areas—and their effectiveness has not been improved by modern science and technology—they restrained the widespread application of CO2-enriched noninvasive treatments.



  • 1845 – “…using naturally occurring carbonated water is the most traditional of therapeutic methods and the most thoroughly studied technique in the field of applied balneo-therapeutics. No natural remedies can make use of such a broad and diverse base of knowledge as carbon dioxide baths (CO2 Balneotherapy).”

– Dr. K. L. Schmidt, Center for Internal Medicine in Bad Nauheim, Germany


  • 1859 – “A sensation of warmth was discovered in CO2 baths and flushing of the skin in the bathed areas of the body.”

– Piderit (1836) and Beneke


  • 1904 – The Bohr Effect was first introduced, describing the oxygen-binding affinity of the hemoglobin as inversely proportional to pH and the concentration of carbon dioxide. In practice, this means that if the carbon dioxide concentration increases somewhere in the body, the hemoglobin molecule will bind to oxygen with lower affinity; therefore, a larger amount of oxygen is released to the area concerned.

– Summation of Christian Bohr’s effect


  • 1928 – “In absorption experiments conducted, it was first demonstrated that CO2 is absorbed by passing through intact skin.”

– Hediger


  • 2003 – “At the end of the 19th century, scientists Bohr and Verigo discovered what seemed a strange law: A decreased level of carbon dioxide in the blood leads to decreased oxygen supply to the cells in the body, including the brain, heart, kidneys, etc. Carbon dioxide (CO2) was found to be responsible for the bond between oxygen and haemoglobin.”

– Dr. Alina Vasiljeva and Dr. David Nias


  • 2004 – “Transdermal CO2 application is a useful method to reduce the risk of infection and improve wound healing in both chronic and certain acute wounds.”

– U. Wollina, MD; Birgit Heinig, Dipl-Med; and Christine Uhlemann, MD


  • 2010 – “Considering the safety, efficacy, and reliability of this method, even if further studies are necessary, we believe that it is useful to include subcutaneous carbon dioxide therapy in the treatment of wounds involving hypoxia-related damage.”

– C. Brandi, L. Grimaldi, G. Nisi, A. Brafa, A. Campa, M. Calabrò, M. Campana, and C. D’Aniello


  • 2014 – “Recommendations for Carbon Dioxide Therapy: Critical Limbic Peripheral Arterial Disease, Mainly Fontaine Stages III–IV. Patients continued traditional medical treatments during therapy.”

– Dr. Gyetvai Gyula Mátraderecske – Parádfürdő


  • 2014 – "The transcutaneous CO2 system enhanced the antitumor action of X-ray irradiation and could be a novel therapeutic tool for overcoming radioresistance in human malignancies."

– Yasuo Onishi1, Toshihiro Akisue1, Teruya Kawamoto1, Takeshi Ueha – Japan

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