WE USE COOKIES TO PROVIDE THE BEST USER EXPERIENCE.

Details Ok
Webshop

Decrease in heart rates by artificial CO2 hot spring bathing is inhibited by beta1-adrenoceptor blockade in anesthetized rats

Masaaki Hashimoto, Noriyuki Yamamoto/Journal of Applied Physiology Published 1 January 2004 Vol. 96 n

CO2

ABSTRACT

To investigate the effects of carbon dioxide (CO2) hot spring baths on physiological functions, head-out immersion of urethane-anesthetized, fursheared male Wistar rats was performed. Animals were immersed in water (30 or 35°C) with high-CO2 content (∼1,000 parts/million; CO2-water). CO2-water for bathing was made by using an artificial spa maker with normal tap water and high-pressure CO2 from a gas cylinder. When a human foot was immersed for 10 min in the CO2-water at 35°C, the immersed skin reddened, whereas skin color did not change in normal tap water at the same temperature. Arterial blood pressure, heart rate (HR), underwater skin tissue blood flow, and temperatures of the colon and immersed skin were continuously measured while animals were immersed in a bathtub of water for ∼30 min at room temperature (26°C). Immersed skin vascular resistance, computed from blood pressure and tissue blood flow, was significantly lower in the CO2-water bath than in tap water at 30°C, but no differences were apparent at 35°C. HR of rats in CO2-water was significantly slower than in tap water at 35°C. Decreased HR in CO2-water was inhibited by infusion of atenolol (β1-adrenoceptor blocker), but it was unaffected by atropine (muscarinic cholinoceptor blocker). Theses results suggest that bradycardia in CO2 hot spring bathing is caused by inhibition of the cardiac sympathetic innervation. This CO2-water maker should prove a useful device for acquiring physiological evidence of balneotherapy.

 

 View and download "DECREASE IN HEART RATES BY ARTIFICIAL CARBON DIOXIDE HOT SPRING BATHING IS INHIBITED BY BETA1-ADRENOCEPTOR BLOCKADE IN ANESTHETIZED RATS." here.

 

Web source: http://jap.physiology.org/content/96/1/226.short 

Share with your friends!