WE USE COOKIES TO PROVIDE THE BEST USER EXPERIENCE.

Details Ok
Webshop

CARbon DIoxide for the treatment of Febrile seizures: rationale, feasibility, and design of the CARDIF-study

Stephanie Ohlraun, Tobias Wollersheim, Claudia Weiß, Peter Martu/Journal of Translational Medicine201311:157 https://doi.org/10.1

CO2

ABSTRACT

Background

2-8% of all children aged between 6 months and 5 years have febrile seizures. Often these seizures cease spontaneously, however depending on different national guidelines, 20-40% of the patients would need therapeutic intervention. For seizures longer than 3-5 minutes application of rectal diazepam, buccal midazolam or sublingual lorazepam is recommended. Benzodiazepines may be ineffective in some patients or cause prolonged sedation and fatigue. Preclinical investigations in a rat model provided evidence that febrile seizures may be triggered by respiratory alkalosis, which was subsequently confirmed by a retrospective clinical observation. Further, individual therapeutic interventions demonstrated that a pCO2-elevation via re-breathing or inhalation of 5% CO2 instantly stopped the febrile seizures. Here, we present the protocol for an interventional clinical trial to test the hypothesis that the application of 5% CO2 is effective and safe to suppress febrile seizures in children.

 

View and download "CARBON DIOXIDE FOR THE TREATMENT OF FEBRILE SEIZURES: RATIONALE, FEASIBILITY, AND DESIGN OF THE CARDIF-STUDY" here.

 

Web Sourse: https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-11-157 

Share with your friends!