Carbon dioxide elimination across the skin was studied in 10 male and five female healthy subjects, sitting in a sealed-body plethysmograph. The following mean values and standard deviations were obtained: male subjects, 0.99 & 0.44, female subjects, 0.39 =t 0.26 (ml/min per m2 of BSA STPD). This sex difference of carbon dioxide elimination is statistically significant. After intramuscular injection of atropine sulphate in six male subjects, carbon dioxide elimination decreased significantly from 1.09 =t 0.53 to 0.48 rt 0.18 (ml/min per m2). Decreased perspiration was observed in the chamber following atropine injection. After application of tepid water to the skin of two atropinized subjects, the carbon dioxide elimination increased to the same level as in the nonatropinized subjects. It appears that increase in the amount of water on or in the skin increases the CO2 elimination.
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